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Cancer Epidemiology and Prevention$
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Michael Thun, Martha S. Linet, James R. Cerhan, Christopher A. Haiman, and David Schottenfeld

Print publication date: 2017

Print ISBN-13: 9780190238667

Published to Oxford Scholarship Online: December 2017

DOI: 10.1093/oso/9780190238667.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 19 October 2021

Biliary Tract Cancer

Biliary Tract Cancer

(p.661) 34 Biliary Tract Cancer
Cancer Epidemiology and Prevention

Jill Koshiol

Catterina Ferreccio

Susan S. Devesa

Juan Carlos Roa

Joseph F. Fraumeni

Oxford University Press

Biliary tract cancers encompass tumors of the gallbladder, extrahepatic bile ducts, and ampulla of Vater. In the United States, biliary tract cancer is the fifth most common malignant neoplasm of the digestive tract, accounting for about 3,700 deaths per year. The gallbladder is the primary subsite for 40% of biliary tract cancers, followed by the extrahepatic bile ducts (33%), ampulla of Vater (20%), and unspecified subsite (8%). Gallbladder cancer occurs twice as often in women than men, while other biliary tumors are more common in men. Risk of gallbladder cancer is elevated in Amerindians, including the Pima Indians in the United States and the Mapuches in Chile, and in certain Hispanic populations. While a significant fraction of these tumors are related to underlying gallstones (cholelithiasis), information on other risk factors is limited, due to the rarity of the tumors, the often rapidly fatal course, and small number of epidemiologic studies.

Keywords:   biliary tract cancers, gallbladder, extrahepatic bile duct, ampulla of Vater, gallstones, epidemiology

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