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Cancer Epidemiology and Prevention$
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Michael Thun, Martha S. Linet, James R. Cerhan, Christopher A. Haiman, and David Schottenfeld

Print publication date: 2017

Print ISBN-13: 9780190238667

Published to Oxford Scholarship Online: December 2017

DOI: 10.1093/oso/9780190238667.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 29 November 2021

Bone Cancers

Bone Cancers

(p.815) 42 Bone Cancers
Cancer Epidemiology and Prevention

Lisa Mirabello

Rochelle E. Curtis

Sharon A. Savage

Oxford University Press

Cancers arising from bone or cartilage account for about 0.2% of malignant neoplasms. They are histologically heterogeneous with multiple rare subtypes. Osteosarcoma and Ewing sarcoma occur primarily in children and young adults, whereas other bone cancers occur in older individuals. As a group, bone cancers have few known environmental risk factors, the exception being a strong association between therapeutic radiation and increased risk of osteosarcoma. The genetic etiology is also better understood in osteosarcoma, although there have been limited studies in other types of bone cancers. This chapter reviews the worldwide incidence of more common types of primary bone cancers, patterns in survival over time, and the associated environmental and genetic risk factors.

Keywords:   osteosarcoma, Ewing sarcoma, bone cancer, sarcoma, therapeutic radiation, risk factor

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