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Cancer Epidemiology and Prevention$
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Michael Thun, Martha S. Linet, James R. Cerhan, Christopher A. Haiman, and David Schottenfeld

Print publication date: 2017

Print ISBN-13: 9780190238667

Published to Oxford Scholarship Online: December 2017

DOI: 10.1093/oso/9780190238667.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 19 October 2021

Penile Cancer

Penile Cancer

(p.1029) 55 Penile Cancer
Cancer Epidemiology and Prevention

Morten Frisch

Oxford University Press

Penile cancers are rare primary malignancies located on the glans, foreskin, or shaft of the penis, excluding the urethra. The vast majority of penile cancers are epithelial tumors representing histological subtypes of squamous cell carcinoma (SCC). Most penile SCCs are believed to develop through pre-invasive lesions known as penile intraepithelial neoplasia and penile carcinoma in situ. They account for 0.1%–0.3% of all incident cancers (excluding non-melanoma skin cancers) in the United States and other developed countries and up to 1% of all cancers in some countries in sub-Saharan Africa. Penile cancers are rare in men younger than 40 years, and are typically diagnosed among men above age 60. The two most important risk factors are pathological phimosis and infection with high-risk types of human papillomaviruses (HPV), both of which are preventable conditions.

Keywords:   cancer, penis, penile cancer, penile intraepithelial neoplasia, human papillomavirus, phimosis

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