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Cancer Epidemiology and Prevention$
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Michael Thun, Martha S. Linet, James R. Cerhan, Christopher A. Haiman, and David Schottenfeld

Print publication date: 2017

Print ISBN-13: 9780190238667

Published to Oxford Scholarship Online: December 2017

DOI: 10.1093/oso/9780190238667.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 19 October 2021

Nervous System

Nervous System

(p.1039) 56 Nervous System
Cancer Epidemiology and Prevention

E. Susan Amirian

Quinn T. Ostrom

Yanhong Liu

Jill Barnholtz-Sloan

Melissa L. Bondy

Oxford University Press

Although brain and other nervous system tumors are relatively rare, constituting up to 4% of incident primary cancer diagnoses, they are often associated with high morbidity and mortality. Several etiologic factors have been examined in relation to nervous system tumors, with the majority of studies focusing on central nervous system tumors. Despite decades of research, the only established risk factors for brain tumors are family history and moderate to high levels of ionizing radiation exposure. Differences in study designs, case ascertainment, control selection, and accuracy of exposure assessment are challenges associated with studying risk factors for nervous system tumors, and may partly explain why the majority of risk for these tumors remains unexplained. There is now substantial evidence that gliomas are inversely associated with allergies and atopy and positively associated with taller height.

Keywords:   nervous system tumors, nervous system, brain tumor, glioma, epidemiology, risk factors

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