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Cancer Epidemiology and Prevention$
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Michael Thun, Martha S. Linet, James R. Cerhan, Christopher A. Haiman, and David Schottenfeld

Print publication date: 2017

Print ISBN-13: 9780190238667

Published to Oxford Scholarship Online: December 2017

DOI: 10.1093/oso/9780190238667.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 19 October 2021

Childhood Cancers

Childhood Cancers

(p.1119) 59 Childhood Cancers
Cancer Epidemiology and Prevention

Eve Roman

Tracy Lightfoot

Susan Picton

Sally Kinsey

Oxford University Press

This chapter addresses the wide range of histological and site-specific cancers that occur before age 25. It considers disease classifications, predisposing factors, and the epidemiology of the most common malignancies seen in children, and adolescents and young adults (AYAs). Cancer before age 25 is rare, accounting for < 2% of diagnoses in economically developed countries. The global burden of childhood cancers is, difficult to quantify, however, since over 80% of the world’s children and AYAs live in economically developing countries, where high morbidity/mortality from infectious disease and nutritional deficiency complicate diagnosis. Both inherited and environmental factors influence cancer risk in children and AYAs, although the relative contribution of each varies widely among cancer subtypes and relatively few causal associations are well established.

Keywords:   childhood cancer, adolescents, young adults, disease classification, malignancy, infectious agents, radiation, morbidity, mortality

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