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Cancer Epidemiology and Prevention$
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Michael Thun, Martha S. Linet, James R. Cerhan, Christopher A. Haiman, and David Schottenfeld

Print publication date: 2017

Print ISBN-13: 9780190238667

Published to Oxford Scholarship Online: December 2017

DOI: 10.1093/oso/9780190238667.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 15 October 2021

Multiple Primary Cancers

Multiple Primary Cancers

(p.1155) 60 Multiple Primary Cancers
Cancer Epidemiology and Prevention

Lindsay M. Morton

Sharon A. Savage

Smita Bhatia

Oxford University Press

As prognosis following a cancer diagnosis has improved and survival has increased, so has the occurrence of multiple primary cancers diagnosed in the same individual. In the United States, one in five cancer diagnoses involves an individual with a previous history of cancer. These new primary cancer diagnoses, or “subsequent neoplasms” (SN), are a substantial cause of morbidity and mortality in cancer survivors. The risk of developing SN varies substantially depending on age, the type of initial primary cancer, chemotherapy, radiotherapy, genetic susceptibility, and exposure to other cancer risk factors. Childhood cancer survivors have particularly elevated SN risks associated with radiotherapy and, to a lesser extent, systemic therapy. Genetic susceptibility to cancer is also thought to play an important role in SN development after childhood cancer. Survivors of many adulthood cancers also have elevated SN risks, likely with a multifactorial etiology.

Keywords:   cancer, subsequent neoplasm, radiotherapy, primary cancer, systemic therapy, genetic susceptibility

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