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Cancer Epidemiology and Prevention

Michael Thun, Martha S. Linet, James R. Cerhan, Christopher A. Haiman, and David Schottenfeld


Since its initial publication in 1982, Cancer Epidemiology and Prevention has served as the premier reference work for both students and professionals working to understand the causes and prevention of cancer in humans. Now revised for the first time in more than a decade, this fourth edition provides an updated and comprehensive summary of the global patterns of cancer incidence and mortality, current understanding of the major causal determinants, and a rationale for preventive interventions. In this edition, special attention has been paid to molecular epidemiologic approaches that address ... More

Keywords: cancer epidemiology, cancer prevention, cancer, gene, environment, mortality, genetic predisposition, etiology

Bibliographic Information

Print publication date: 2017 Print ISBN-13: 9780190238667
Published to Oxford Scholarship Online: December 2017 DOI:10.1093/oso/9780190238667.001.0001


Affiliations are at time of print publication.

Michael Thun, editor
Vice President Emeritus of Epidemiology and Surveillance Research, American Cancer Society

Martha S. Linet, editor
Senior Investigator, Division of Cancer Epidemiology, National Cancer Institute

James R. Cerhan, editor
Professor of Epidemiology, Ralph S. and Beverly Caulkins Professor of Cancer Research, and Chair of the Department of Health Sciences Research, Mayo Clinic College of Medicine

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1 Introduction

Michael J. Thun, Martha S. Linet, James R. Cerhan, Christopher A. Haiman, and David Schottenfeld

I Basic Concepts

2 Biology of Neoplasia

Michael Dean and Karobi Moitra

3 Morphological and Molecular Classification of Human Cancer

Mark E. Sherman, Melissa A. Troester, Katherine A. Hoadley, and William F. Anderson

4 Genomic Landscape of Cancer

Christopher J. Maher and Elaine R. Mardis

5 Genetic Epidemiology of Cancer

Kathryn L. Penney, Kyriaki Michailidou, Deanna Alexis Carere, Chenan Zhang, Brandon Pierce, Sara Lindström, and Peter Kraft

6 Application of Biomarkers in Cancer Epidemiology

Roel Vermeulen, Douglas A. Bell, Dean P. Jones, Montserrat Garcia-Closas, Avrum Spira, Teresa W. Wang, Martyn T. Smith, Qing Lan, and Nathaniel Rothman

7 Causal Inference in Cancer Epidemiology

Steven N. Goodman and Jonathan M. Samet

II The Magnitude of Cancer

8 Patterns of Cancer Incidence, Mortality, and Survival

Ahmedin Jemal, D. Maxwell Parkin, AND Freddie Bray

10 The Economic Burden of Cancer in the United States

K. Robin Yabroff, Gery P. Guy Jr., Matthew P. Banegas, and Donatus U. Ekwueme

III The Causes of Cancer

11 Tobacco

Michael J. Thun and Neal D. Freedman

12 Alcohol and Cancer Risk

Susan M. Gapstur and Philip John Brooks

13 Ionizing Radiation

Amy Berrington de GonzÁlez, André Bouville, Preetha Rajaraman, and Mary Schubauer-Berigan

14 Ultraviolet Radiation

Adèle C. Green and David C. Whiteman

15 Electromagnetic Fields

Maria Feychting and Joachim Schüz

16 Occupational Cancer

Kyle Steenland, Shelia Hoar Zahm, and A. Blair

17 Air Pollution

Jonathan M. Samet and Aaron J. Cohen

18 Water Contaminants

Kenneth P. Cantor, Craig M. Steinmaus, Mary H. Ward, and Laura E. Beane Freeman

19 Diet and Nutrition

Marjorie L. McCullough and Walter C. Willett

20 Obesity and Body Composition

NaNa Keum, Mingyang Song, Edward L. Giovannucci, and A. Heather Eliassen

21 Physical Activity, Sedentary Behaviors, and Risk of Cancer

Steven C. Moore, Charles E. Matthews, Sarah Keadle, Alpa V. Patel, and I-Min Lee

22 Hormones and Cancer

Robert N. Hoover, Amanda Black, and Rebecca Troisi

23 Pharmaceutical Drugs Other Than Hormones

Marie C. Bradley, Michael A. O’Rorke, Janine A. Cooper, Søren Friis, and Laurel A. Habel

24 Infectious Agents

Silvia Franceschi, Hashem B. El-Serag, David Forman, Robert Newton, and Martyn Plummer

25 Immunologic Factors

Eric A. Engels and Allan Hildesheim

IV Cancers by Tissue of Origin

26 Nasopharyngeal Cancer

Ellen T. Chang and Allan Hildesheim

27 Cancer of the Larynx

Andrew F. Olshan and Mia Hashibe

28 Lung Cancer

Michael J. Thun, S. Jane Henley, and William D. Travis

29 Oral Cavity, Oropharynx, Lip, and Salivary Glands

Mia Hashibe, Erich M. Sturgis, Jacques Ferlay, and Deborah M. Winn

30 Esophageal Cancer

William J. Blot and Robert E. Tarone

31 Stomach Cancer

Catherine de Martel and Julie Parsonnet

32 Cancer of the Pancreas

Samuel O. Antwi, Rick J. Jansen, and Gloria M. Petersen

33 Liver Cancer

W. Thomas London, Jessica L. Petrick, and Katherine A. McGlynn

34 Biliary Tract Cancer

Jill Koshiol, Catterina Ferreccio, Susan S. Devesa, Juan Carlos Roa, and Joseph F. Fraumeni, Jr.

35 Small Intestine Cancer

Jennifer L. Beebe-Dimmer, Fawn D. Vigneau, and David Schottenfeld

36 Cancers of the Colon and Rectum

Kana Wu, NaNa Keum, Reiko Nishihara, and Edward L. Giovannucci

37 Anal Cancer

Andrew E. Grulich, Fengyi Jin, and I. Mary Poynten

38 Leukemias

Martha S. Linet, Lindsay M. Morton, Susan S. Devesa, and Graça M. Dores

39 Hodgkin Lymphoma

Henrik Hjalgrim, Ellen T. Chang, and Sally L. Glaser

40 The Non-Hodgkin Lymphomas

James R. Cerhan, Claire M. Vajdic, and John J. Spinelli

41 Multiple Myeloma

Mark P. Purdue, Jonathan N. Hofmann, Elizabeth E. Brown, and Celine M. Vachon

42 Bone Cancers

Lisa Mirabello, Rochelle E. Curtis, and Sharon A. Savage

43 Soft Tissue Sarcoma

Marianne Berwick and Charles Wiggins

44 Thyroid Cancer

Cari M. Kitahara, Arthur B. Schneider, and Alina V. Brenner

45 Breast Cancer

Louise A. Brinton, Mia M. Gaudet, and Gretchen L. Gierach

46 Ovarian Cancer

Shelley S. Tworoger, Amy L. Shafrir, and Susan E. Hankinson

47 Endometrial Cancer

Linda S. Cook, Angela L. W. Meisner, and Noel S. Weiss

48 Cervical Cancer

Rolando Herrero and Raul Murillo

49 Vulvar and Vaginal Cancers

Margaret M. Madeleine and Lisa G. Johnson

50 Choriocarcinoma

Julie R. Palmer

51 Renal Cancer

Wong-Ho Chow, Ghislaine Scelo, and Robert E. Tarone

52 Bladder Cancer

Debra T. Silverman, Stella Koutros, Jonine D. Figueroa, Ludmila Prokunina-Olsson, and Nathaniel Rothman

53 Prostate Cancer

Catherine M. Tangen, Marian L. Neuhouser, and Janet L. Stanford

54 Testicular Cancer

Katherine A. McGlynn, Ewa Rajpert-De Meyts, and Andreas Stang

55 Penile Cancer

Morten Frisch

56 Nervous System

E. Susan Amirian, Quinn T. Ostrom, Yanhong Liu, Jill Barnholtz-Sloan, and Melissa L. Bondy

57 Melanoma

Bruce K. Armstrong, Claire M. Vajdic, and Anne E. Cust

58 Keratinocyte Cancers

Anala Gossai, Dorothea T. Barton, Judy R. Rees, Heather H. Nelson, and Margaret R. Karagas

59 Childhood Cancers

Eve Roman, Tracy Lightfoot, Susan Picton, and Sally Kinsey

60 Multiple Primary Cancers

Lindsay M. Morton, Sharon A. Savage, and Smita Bhatia

V Cancer Prevention and Control

61 Framework for Understanding Cancer Prevention

Michael J. Thun, Christopher P. Wild, and Graham Colditz

62 Primary Prevention of Cancer

Michael J. Thun, Martha S. Linet, James R. Cerhan, Christopher Haiman, and David Schottenfeld

62.1 Tobacco Control

Jeffrey Drope, Clifford E. Douglas, and Brian D. Carter

62.3 Prevention of Infection-Related Cancers

Marc Bulterys, Julia Brotherton, and Ding-Shinn Chen

62.4 Protection from Ultraviolet Radiation

Robyn M. Lucas, Rachel E. Neale, Peter Gies, and Terry Slevin

62.6 Regulation

Jonathan M. Samet and Lynn Goldman

63 Cancer Screening

Jennifer M. Croswell, Russell P. Harris, and Barnett S. Kramer

End Matter