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Vascular Disease, Alzheimer's Disease, and Mild Cognitive Impairment – Advancing an Integrated Approach - Oxford Scholarship Online
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Vascular Disease, Alzheimer's Disease, and Mild Cognitive Impairment: Advancing an Integrated Approach

David J. Libon, Melissa Lamar, Rodney A. Swenson, and Kenneth M. Heilman

Abstract

Alzheimer’s disease and vascular dementia are acknowledged as the two most common types of dementia. Each of these dementia syndromes are associated with prodromal clinical syndromes, often referred to as mild cognitive impairment. Recent research has demonstrated considerable heterogeneity regarding the underlying neuropathology associated with these dementia syndromes and their prodromal disorders. Thus, it is often difficult to understand how or what underlying biological substrate is actually responsible for the alterations in neurocognition and behaviour as seen in clinical evaluations. T ... More

Keywords: Alzheimer’s disease, vascular dementia, mild cognitive impairment, heterogenity, blood brain barrier

Bibliographic Information

Print publication date: 2020 Print ISBN-13: 9780190634230
Published to Oxford Scholarship Online: June 2020 DOI:10.1093/oso/9780190634230.001.0001

Authors

Affiliations are at time of print publication.

David J. Libon, editor
Professor of Geriatrics, Gerontology, and Psychology, Rowan University

Melissa Lamar, editor
Associate Professor, Rush Alzheimer's Disease Center

Rodney A. Swenson, editor
Clinical Professor of Psychiatry and Behavioral Science, University of North Dakota School of Medicine and Health Sciences

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Contents

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Part 1 Epidemiology and Neuropsychology

1 Vascular Risk Factors and Their Relationship to Brain Aging

Ting Fang Alvin Ang, Prajakta Joshi, and Rhoda Au

2 Heterogeneity in Alzheimer’s/Vascular Spectrum Dementia

Sheina Emrani, Melissa Lamar, Catherine C. Price, Victor Wasserman, Emily Matusz, Rodney A. Swenson, Kenneth M. Heilman, and David J. Libon

3 Neuropsychological Contributions to the Diagnosis of Mild Cognitive Impairment Associated With Alzheimer’s Disease

Joel Eppig, Madeleine Werhane, Emily C. Edmonds, Lisa-Delano Wood, Katherine J. Bangen, Amy Jak, Kelsey R. Thomas, Christina Wong, Alexandra Weigand, and Mark W. Bondi

4 Vascular Cognitive Impairment

Victor Wasserman, Sheina Emrani, Emily Matusz, Catherine C. Price, Melissa Lamar, Rodney A. Swenson, Kenneth M. Heilman, and David J. Libon

6 Heterogeneity in Dementia and Mild Cognitive Impairment

Deborah A. G. Drabick and Jill Rabinowitz

Part 2 Neuroimaging

8 Cerebral Small Vessel Disease and the Risk of Dementia and Cognition Decline

Emilia Salvadori, Fabio Fierini, and Leonardo Pantoni

9 Structural MRI in Alzheimer’s Disease

Briana S. Last, Batool Rizvi, and Adam M. Brickman

10 Brain Structural Alterations Common to Cardiovascular Disease Risk Factors and Alzheimer’s Dementia

Melissa Lamar, Elizabeth A. Boots, Konstantinos Arfanakis, Lisa L. Barnes, and Julie A. Schneider

Part 3 Blood–Brain Barrier and Cardiogenic Mechanisms

Part 4 Neuropathological and Neurophysiological Mechanisms

16 Unraveling the Role of Mitochondria in Alzheimer’s Disease

Sónia C. Correia, Paula I. Moreira, and George Perry

Part 5 Treatment and Intervention

17 Cognitive Change and Elective Surgeries With Anesthesia

Margaret E. Wiggins, Carlos Hernaiz, Brenda G. Fahy, and Catherine C. Price

18 Management of Mild Cognitive Impairment

Ramit Ravona-Springer and Amos D. Korczyn

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