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Epidemiology by DesignA Causal Approach to the Health Sciences$
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Daniel Westreich

Print publication date: 2019

Print ISBN-13: 9780190665760

Published to Oxford Scholarship Online: December 2019

DOI: 10.1093/oso/9780190665760.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 03 December 2021

Randomized Trials

Randomized Trials

(p.107) 5 Randomized Trials
Epidemiology by Design

Daniel Westreich

Oxford University Press

In Chapter 5, the author describes randomized trials. The chapter gives a broad overview of types of trials and the steps in conducting a trial and also describes how trials meet (and fail to meet) core causal identification conditions. The author provides a brief introduction to the analysis of randomized trial data. As well, the chapter introduces factorial trials as well as subgroup analysis of trials as a way of explaining differences between causal interaction and effect measure modification. Finally, the author describes issues in the generalizability and transportability of trials and quantitative approaches to these issues.

Keywords:   randomized trials, blinding, subgroup analysis, factorial trials, Kaplan-Meier curves, internal validity, external validity, intention-to-treat, compliance-corrected analysis, lost to follow-up

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