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The Science of Marijuana$
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Leslie Iversen

Print publication date: 2019

Print ISBN-13: 9780190846848

Published to Oxford Scholarship Online: November 2018

DOI: 10.1093/oso/9780190846848.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 01 December 2021

The Pharmacology of Delta-9-Tetrahydrocannabinol (THC)

The Pharmacology of Delta-9-Tetrahydrocannabinol (THC)

(p.21) Chapter 2 The Pharmacology of Delta-9-Tetrahydrocannabinol (THC)
The Science of Marijuana

Leslie Iversen

Oxford University Press

The 19th century was a great era for plant chemistry. Many complex drug molecules, known as alkaloids, were isolated and identified from plants. This chapter discusses the history of the discovery of delta-9-tetrahyrocannabinol (THC) as the psychoactive substance in cannabis products and also the discovery of the cannabinoid receptors CB-1 and CB-2 in the body and brain. The mechanism of action of cannabinoids on such receptors to inhibit neurotransmitter release or other actions is also discussed. In addition, various methods for the ingestion of cannabis, such as smoking and vaping, are reviewed. Synthetic agonists and antagonists at cannabinoid receptors and the proliferation of synthetic agonists as novel psychoactive agents are also discussed.

Keywords:   delta-9-tetrahyrocannabinol, THC, cannabinoid receptors, smoking, vaping, “Spice, ” synthetic cannabis agonists

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