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The Science of Marijuana$
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Leslie Iversen

Print publication date: 2019

Print ISBN-13: 9780190846848

Published to Oxford Scholarship Online: November 2018

DOI: 10.1093/oso/9780190846848.001.0001

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Peripheral and Central Effects of THC

Peripheral and Central Effects of THC

(p.61) Chapter 3 Peripheral and Central Effects of THC
The Science of Marijuana

Leslie Iversen

Oxford University Press

Although there is currently only limited knowledge of how activation of the CB-1 receptor in brain leads to the many actions of THC, some general features of cannabinoid control mechanisms are emerging. This chapter discusses THC in relation to the inhibition of neurotransmitter release, cardiovascular effects, effects on motility and pain, and behavioral models including the “Billy Martin tetrad.” It also discusses human laboratory models, including studies on learning and memory. A key effect of cannabis is intoxication, and the subjective effects of cannabis are reported in detail. Finally, the value of animal behavior studies is discussed, including discriminative stimulus effects, effects on cognition, and anti-anxiety effects.

Keywords:   cardiovascular effects, motility, pain, cognition, discriminative effects, anti-anxiety

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