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Complex Systems and Population Health

Yorghos Apostolopoulos, Michael K. Lemke, and Kristen Hassmiller Lich


Currently, population health science is an integral part of academic curricula around the world. For over a century, the principles of the reductionist paradigm have guided population health curricula, training, research, and action. Researchers continue to draw upon these principles when theorizing, conceptualizing, designing studies, analyzing, and devising interventions to tackle complex population health problems. However, unresolved impasses in delineating and managing pressing population health challenges have catalyzed calls for the integration of complex systems science–grounded theore ... More

Keywords: population health science, complex systems science, complex adaptive systems, network science, methodology, mathematical modeling, simulation modeling

Bibliographic Information

Print publication date: 2020 Print ISBN-13: 9780190880743
Published to Oxford Scholarship Online: July 2020 DOI:10.1093/oso/9780190880743.001.0001


Affiliations are at time of print publication.

Yorghos Apostolopoulos, editor
Associate Professor of Population Health and Founding Director of the Complexity & Computational Population Health Group, Texas A&M University

Michael K. Lemke, editor
Associate Director of the Complexity & Computational Population Health Group, Texas A&M University

Kristen Hassmiller Lich, editor
Associate Professor in the Department of Health Policy and Management, University of North Carolina at Chapel Hill

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Part I Population Health Science in a Complex World

1 Bridging the Divide

Yorghos Apostolopoulos

2 Complex Systems in a Nutshell

Megan S. Patterson, Michael K. Lemke, and Jordan Nelon

4 Complex Network Dynamics in Population Health

James Moody and Dana K. Pasquale

5 Phase Transitions and Resilience in Physical and Psychological Health

Marcel G. M. Olde Rikkert, Noemi Schuurman, and René J. F. Melis

11 Mathematical Modeling in Population Health Research

Karen Hicklin and Kristen Hassmiller Lich

13 System Dynamics Modeling to Rethink Health System Reform

Jack Homer, Bobby Milstein, and Gary B. Hirsch

14 Agent-Based Modeling to Delineate Opioid and Other Drug Use Epidemics

Georgiy V. Bobashev, Lee D. Hoffer, and Francois R. Lamy

15 Hybrid Simulation Modeling in Population Health

Sally C. Brailsford, Dave C. Evenden, and Joe Viana

16 Validation of Microsimulation Models Used for Population Health Policy

Fernando Alarid-Escudero, Roman Gulati, and Carolyn M. Rutter

Part V Toward a New Population Health Science

20 Harnessing Complex Systems

Yorghos Apostolopoulos