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Neuroscience of Enduring Change

Richard D. Lane and Lynn Nadel


The field of psychotherapy began over 100 years with the hope that its neural foundations could be understood. Since then, the field of neuroscience has burgeoned such that it is now possible to envision in a rudimentary way what brain mechanisms may participate in bringing about meaningful and enduring change. A key development has been the discovery that memories are not fixed but can be updated under certain circumstances, a process known as memory reconsolidation. This is critical because memories guide future behavior as well as provide a record of the past. Another foundational discovery ... More

Keywords: psychotherapy, neuroscience, memory, emotion, memory–emotion interactions, memory reconsolidation, computational psychiatry

Bibliographic Information

Print publication date: 2020 Print ISBN-13: 9780190881511
Published to Oxford Scholarship Online: March 2020 DOI:10.1093/oso/9780190881511.001.0001


Affiliations are at time of print publication.

Richard D. Lane, editor
University of Arizona

Lynn Nadel, editor
University of Arizona

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Part I Overview

Part II Basic Science Perspectives

4 The Role of Language in the Construction of Emotion and Memory

Ajay B. Satpute, Erik C. Nook, and Melis E. Cakar

5 Dynamic Regulation of Internal Experience

Jessica R. Andrews-Hanna, Kalina Christoff, and Mary-Frances O’Connor

6 Emotion–Memory Interactions

Joseph E. Dunsmoor and Marijn C. W. Kroes

8 Autobiographical Memory and the Self-Concept

Matthew D. Grilli and Lee Ryan

Part III Clinical Psychotherapy Perspectives

9 Emotion-Focused Therapy

Antonio Pascual-Leone and Leslie Greenberg

10 CBT for Anxiety Disorders

Jonathan D. Huppert, Isaac Fradkin, and Shawn P. Cahill

13 Memory Reconsolidation as a Common Change Process

Rhonda Goldman and Alyssa Fredrick-Keniston

Part IV Integrative Perspectives

15 A Computational Neuroscience Perspective on the Change Process in Psychotherapy

Ryan Smith, Richard D. Lane, Lynn Nadel, and Michael Moutoussis

16 Neuroscience of Enduring Change and Psychotherapy

Richard D. Lane, Ryan Smith, and Lynn Nadel

End Matter