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William W. Eaton and M. Daniele Fallin

Print publication date: 2019

Print ISBN-13: 9780190916602

Published to Oxford Scholarship Online: June 2019

DOI: 10.1093/oso/9780190916602.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 21 June 2021

Genes as a Source of Risk for Mental Disorders

Genes as a Source of Risk for Mental Disorders

(p.223) 9 Genes as a Source of Risk for Mental Disorders
Public Mental Health

Peter P. Zandi

Holly C. Wilcox

Yian Lin

Brion Maher

M. Daniele Fallin

Oxford University Press

This chapter introduces the reader to the concept of genetics and disease and includes review of more than 200 family, twin, and adoption studies for six important mental and behavioral disorders. The heritability estimates range from 30% for depressive disorder to as high as 80% for schizophrenia. Genome-wide association and sequencing studies are beginning to identify genetic risk variants associated with these disorders, but a large proportion of the genetic contribution remains unexplained. Major challenges in genetic studies include defining and agreeing on the phenotype that should be the subject of the study and the apparent complexity of the genetic etiology. In the near future, as larger samples with more detailed phenotype information are studied, a clear picture of the underlying genetic architecture of mental and behavioral disorders will emerge.

Keywords:   phenotype, familial recurrence risk, heritability, DNA, linkage, sequencing, genome-wide association, candidate gene

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