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Genes, brain, and emotionsInterdisciplinary and Translational Perspectives$
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Andrei C. Miu, Judith R. Homberg, and Klaus-Peter Lesch

Print publication date: 2019

Print ISBN-13: 9780198793014

Published to Oxford Scholarship Online: June 2019

DOI: 10.1093/oso/9780198793014.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 27 July 2021

Missing heritability in studies of trait anxiety and amygdala function

Missing heritability in studies of trait anxiety and amygdala function

Is the solution in plain sight?

(p.205) Chapter 14 Missing heritability in studies of trait anxiety and amygdala function
Genes, brain, and emotions

Turhan Canli

Oxford University Press

Ask any parent how early they could discern the temperament of their child, or when they noticed differences in temperament among their children, and the answer is likely to be: “almost immediately.” Anecdotally, personality traits are present from the first days of life and remain relatively stable throughout its course, suggesting a strong biological basis for these predispositions. Behavioral geneticists have quantified the heritability of personality traits, and molecular studies have eagerly sought to discover their associated genes. Curiously, the anticipated bonanza of gene discoveries has not materialized: heritability has gone missing. This chapter discusses the view on missing heritability and argues that current approaches have fallen short of expectations. Four ways in which missing heritability may be hiding in plain sight are presented. The chapter concludes by highlighting future directions for research that will hopefully find what has been missing thus far from our understanding of genes, brains, and behavioral traits.

Keywords:   behavioral genetics, molecular genetics, genomics, missing heritability, epigenetics, genome-wide association studies, heritability

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