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Genes, brain, and emotionsInterdisciplinary and Translational Perspectives$
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Andrei C. Miu, Judith R. Homberg, and Klaus-Peter Lesch

Print publication date: 2019

Print ISBN-13: 9780198793014

Published to Oxford Scholarship Online: June 2019

DOI: 10.1093/oso/9780198793014.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 28 October 2021

Imaging genetics in depression

Imaging genetics in depression

Chapter:
(p.235) Chapter 16 Imaging genetics in depression
Source:
Genes, brain, and emotions
Author(s):

Ulrich Rabl

Lukas Pezawas

Publisher:
Oxford University Press
DOI:10.1093/oso/9780198793014.003.0016

In recent years, the demand for more efficient psychiatric diagnostics and treatments has stimulated an unprecedented effort in clinical, genetic, and imaging research with the goal to realize the promise of precision medicine and develop new therapeutic approaches. Major depressive disorder (MDD), which is highly prevalent and ranks among the top causes of disability worldwide, has been one of the central subjects in this story. Since the turn of the millennium, researchers began to amalgamate methods from psychiatric genetics and clinical neuroimaging to uncover the effects of genetic variation at the level of brain function, structure or connectivity. This line of research, imaging genetics, matured to a distinct research field that became a major force in the quest for understanding the neurobiology underlying MDD and the implications of the serotonergic system. This chapter provides an overview of the development and impact of imaging genetics research with a focus on MDD and the serotonergic system and discusses the barriers and solutions on the way to clinical implementation.

Keywords:   MDD, imaging genetics, functional magnetic resonance imaging, SLC6A4, BDNF, COMT, gene–environment interaction

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