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Genes, brain, and emotionsInterdisciplinary and Translational Perspectives$
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Andrei C. Miu, Judith R. Homberg, and Klaus-Peter Lesch

Print publication date: 2019

Print ISBN-13: 9780198793014

Published to Oxford Scholarship Online: June 2019

DOI: 10.1093/oso/9780198793014.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 30 July 2021

The genetics of personality/psychopathology

The genetics of personality/psychopathology

A brief review of constructs, results, approaches, and implications

(p.275) Chapter 19 The genetics of personality/psychopathology
Genes, brain, and emotions

Thomas J Bouchard

Wendy Johnson

Irving I Gottesman

Oxford University Press

The chapter argues that the best evidence supports the contention that psychiatric “conditions” are not discrete “disorders” but rather dimensional and part of the personality sphere. The personality traits that imply dysfunction are positively correlated, implying a general “p” factor analogous to the “g” factor in the domain of mental ability. There are very many personality traits that can be defined in multiple ways and all are influenced by many genes of very small effect. These facts suggest that the biological causes of variation in personality and psychopathology are likely varied and heterogeneous. We note the seldom discussed fact that the brain is a “kludgy” organ due to the way it evolved. It is likely that explanations of psychopathology will also be “kludgy.” Nevertheless, current research suggests that we are making sure but slow progress.

Keywords:   personality, psychopathology, genes, quantitative genetics, molecular genetics, heritability, twins, GWAS

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