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Genes, brain, and emotionsInterdisciplinary and Translational Perspectives$
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Andrei C. Miu, Judith R. Homberg, and Klaus-Peter Lesch

Print publication date: 2019

Print ISBN-13: 9780198793014

Published to Oxford Scholarship Online: June 2019

DOI: 10.1093/oso/9780198793014.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 30 July 2021

Genetics of impulsivity, anger, and aggression as risk factors for suicidal behavior

Genetics of impulsivity, anger, and aggression as risk factors for suicidal behavior

Chapter:
(p.343) Chapter 23 Genetics of impulsivity, anger, and aggression as risk factors for suicidal behavior
Source:
Genes, brain, and emotions
Author(s):

Dan Rujescu

Ina Giegling

Publisher:
Oxford University Press
DOI:10.1093/oso/9780198793014.003.0023

Suicidal behavior is a major health problem causing more than 1 million deaths worldwide each year. The risk of suicide-related behavior is supposed to be determined by a complex interplay of sociocultural factors, psychiatric history, personality traits, and genetic as well as neurobiological vulnerability. Personality traits like impulsivity, anger or aggression are valuable intermediate phenotypes in the search for the genetics of such a complex trait. This review will summarize genetic factors of phenotypes as risk factors for suicidal behavior. There is hope that simpler, quantifiable measures will be more elementary compared to clinical phenotypes. It is assumed that the number of genes required to produce variations in these traits may be fewer than those involved in producing a diagnostic entity. Further understanding of the genetics and pathophysiology of suicidal behavior is therefore very important.

Keywords:   suicidal behavior, impulsivity, aggression, anger, genetics, genes, intermediate phenotype

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