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Genes, brain, and emotionsInterdisciplinary and Translational Perspectives$
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Andrei C. Miu, Judith R. Homberg, and Klaus-Peter Lesch

Print publication date: 2019

Print ISBN-13: 9780198793014

Published to Oxford Scholarship Online: June 2019

DOI: 10.1093/oso/9780198793014.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 27 July 2021

The role of pharmacogenetics in the treatment of depression

The role of pharmacogenetics in the treatment of depression

(p.421) Chapter 27 The role of pharmacogenetics in the treatment of depression
Genes, brain, and emotions

Airiss R Chan

Ilona Gorbovskaya

Daniel J Müller

Oxford University Press

Antidepressants are the primary form of pharmacotherapy in the treatment of depression and anxiety, however they have been known to vary widely in response and cause undesirable adverse effects among patients. As antidepressant response has been proven to have a genetic basis, pharmacogenetics may hold the key to unlocking personalized medicine, which can greatly benefit patients, physicians, and the healthcare system. This chapter addresses the current stance in psychiatric pharmacogenetics, and discusses the outlook for the field. Within depression and anxiety, variants within the cytochrome P450 enzymes, the serotonin transporter, and the norepinephrine transporter genes have yielded the strongest findings. With respect to clinical applicability, there is wide consensus for use of pharmacokinetic genes to inform treatment and to mitigate adverse events, while recommendations to include pharmacodynamic genes remain inconclusive. This testifies to the need for further research and to test genetically based algorithms.

Keywords:   pharmacogenetics, psychopharmacology, antidepressants, depression, drug metabolism, pharmacokinetics, pharmacodynamics, personalized medicine, psychiatry

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