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Genes, brain, and emotionsInterdisciplinary and Translational Perspectives$
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Andrei C. Miu, Judith R. Homberg, and Klaus-Peter Lesch

Print publication date: 2019

Print ISBN-13: 9780198793014

Published to Oxford Scholarship Online: June 2019

DOI: 10.1093/oso/9780198793014.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 27 July 2021

Genome-wide association studies

Genome-wide association studies

(p.51) Chapter 5 Genome-wide association studies
Genes, brain, and emotions

Thomas W Mühleisen

Sven Cichon

Oxford University Press

Genome-wide association studies (GWAS) have evolved over the past ten years into a very successful tool for investigating the genetic architecture of multifactorial human traits and disorders. One major advantage of GWAS is that they do not require any a priori knowledge about the biological mechanisms underlying the traits and disorders under study. This chapter describes the scientific and technological developments that made GWAS possible and the underlying basic concept of these studies. The chapter considers what has been learned from GWAS in psychiatric research so far, what are the limitations, and looks forward to the future of GWAS.

Keywords:   single-nucleotide polymorphism (SNP), complex genetics, multifactorial, gene identification, genotyping, microarrays

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