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Genes, brain, and emotionsInterdisciplinary and Translational Perspectives$
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Andrei C. Miu, Judith R. Homberg, and Klaus-Peter Lesch

Print publication date: 2019

Print ISBN-13: 9780198793014

Published to Oxford Scholarship Online: June 2019

DOI: 10.1093/oso/9780198793014.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 27 July 2021

Methods and theoretical approaches

Methods and theoretical approaches

Genetic animal models of emotional disorders and convergence with human data

(p.77) Chapter 7 Methods and theoretical approaches
Genes, brain, and emotions

Celine L St Pierre

Kayvon Sharif

Emily Funsten

Abraham A Palmer

Clarissa C Parker

Oxford University Press

Anxiety, depression, and stress-related disorders are complex neurobehavioral diseases with a partially heritable genetic basis. This chapter explores how the appropriate use of rodent models can illuminate the neurobiological underpinnings of these disorders. Because these psychiatric disorders are uniquely human, rodent models typically model individual components rather than trying to recapitulate the disease itself. This chapter considers how both intermediate phenotypes and rodent models fit into this framework. Integrating these two concepts can be bidirectional: studying intermediate phenotypes in rodent models may lead to identifying risk genes that are present in humans, or human studies may uncover genetic variants linked to intermediate phenotypes and subsequent experiments in rodents may be employed to examine the causal mechanisms. This dynamic interplay is explored throughout the chapter.

Keywords:   genetic, models, rodent, methods, behavior, disorders, depression, anxiety, stress

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