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Genes, brain, and emotionsInterdisciplinary and Translational Perspectives$
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Andrei C. Miu, Judith R. Homberg, and Klaus-Peter Lesch

Print publication date: 2019

Print ISBN-13: 9780198793014

Published to Oxford Scholarship Online: June 2019

DOI: 10.1093/oso/9780198793014.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 27 July 2021

Optogenetic and chemogenetic technologies for advanced functional investigations of the neural correlates of emotions

Optogenetic and chemogenetic technologies for advanced functional investigations of the neural correlates of emotions

Chapter:
(p.97) Chapter 8 Optogenetic and chemogenetic technologies for advanced functional investigations of the neural correlates of emotions
Source:
Genes, brain, and emotions
Author(s):

Alexandre Surget

Catherine Belzung

Publisher:
Oxford University Press
DOI:10.1093/oso/9780198793014.003.0008

The neural circuits underlying emotions have been extensively examined in the last decades, using either correlational approaches (e.g. functional imaging in human subjects or post-mortem immunohistochemistry in rodents) or methodologies enabling to investigate causal relationships (such as focused brain lesions in animals). However, each of these approaches has strong limitations that have hampered research in this field. The first approaches do not enable investigation of causal relations; they allow determining associations of particular emotional expressions with distinct cell populations or brain areas. The second approach enables the determination of causal relations but not the inhibition of particular cell types or projections or the investigation of the effects of manipulating neuronal activity during a restricted time period. Optogenetic and chemogenetic approaches are two cutting-edge methodologies that enabled ground-breaking research in the field of emotion in recent years. These approaches make possible the stimulation or inhibition of specific neuronal populations/projections in a specific area of the brain, during a precise period of time, thus permitting the dissection of the contribution of precise neuronal populations, sub-areas, and outputs to the different components of emotions. It is strongly impacting research in this field, providing a more complex and rich view of the biology of normal emotions.

Keywords:   fear, emotions, optogenetic, chemogenetic, neural circuits

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