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Introduction to Perfusion Quantification using Arterial Spin Labelling - Oxford Scholarship Online
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Introduction to Perfusion Quantification using Arterial Spin Labelling

Michael Chappell, Bradley MacIntosh, and Thomas Okell


Arterial spin labeling (ASL) magnetic resonance imaging (MRI) is unique in being a completely non-invasive method for imaging perfusion in the brain. Relying upon a blood-borne tracer that is created by the MRI scanner itself, ASL is becoming a popular tool to study cerebral perfusion, as well as how this perfusion changes in response to neuronal activity or in disease. This primer provides an introduction to perfusion quantification using ASL MRI, focusing both on the methods needed to extract perfusion-weighted images and on how to quantify perfusion and other hemodynamic parameters. Startin ... More

Keywords: cerebral blood flow, perfusion, arterial spin labeling, ASL, magnetic resonance imaging, MRI, functional MRI, neuroimaging

Bibliographic Information

Print publication date: 2017 Print ISBN-13: 9780198793816
Published to Oxford Scholarship Online: December 2017 DOI:10.1093/oso/9780198793816.001.0001


Affiliations are at time of print publication.

Michael Chappell, author
Associate Professor of Engineering Science, Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, UK

Bradley MacIntosh, author
Associate Professor and Neuroimaging Scientist, Department of Medical Biophysics, University of Toronto, Canada

Thomas Okell, author
University Research Lecturer, Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, UK