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Pertussis – Epidemiology, Immunology, and Evolution - Oxford Scholarship Online
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Pertussis: Epidemiology, Immunology, and Evolution

Pejman Rohani and Samuel Scarpino


Pertussis, or whooping cough, is a respiratory disease caused primarily by infection with the bacterium Bordetella pertussis. It remains one of the leading causes of death among vaccine-preventable diseases worldwide and recent years have seen its alarming re-emergence in many regions (including the United States and much of Europe), despite sustained high levels of vaccine coverage. The causes of the resurgence remain contentious, in part due to inherent complexities of the pathogen’s biology, in part due to pronounced variation in the treatment and prevention strategies between different cou ... More

Keywords: pertussis, whooping cough, epidemiology, immunology, pathogen evolution, transmission, vaccines, mathematical models, inference, genomics

Bibliographic Information

Print publication date: 2018 Print ISBN-13: 9780198811879
Published to Oxford Scholarship Online: February 2019 DOI:10.1093/oso/9780198811879.001.0001


Affiliations are at time of print publication.

Pejman Rohani, editor
Professor, Odum School of Ecology & Department of Infectious Diseases, University of Georgia, USA

Samuel Scarpino, editor
Assistant Professor, Network Science Institute at Northeastern University, USA

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Pejman Rohani and Samuel V. Scarpino

Chapter 2 Basics of pertussis pathogenesis

Amanda L. Skarlupka, Bodo Linz, Jennifer Maynard, and Eric T. Harvill

Chapter 3 The immunology of Bordetella pertussis infection and vaccination

Mieszko M. Wilk, Aideen C. Allen, Alicja Misiak, Lisa Borkner, and Kingston H.G. Mills

Chapter 4 Pertussis epidemiology

Natasha Crowcroft and Elizabeth Miller

Chapter 5 Role of vaccine schedules

Jodie McVernon and Hester de Melker

Chapter 6 Animal models

Eric T. Harvill and Tracy Nicholson

Chapter 7 The human immune responses to pertussis and pertussis vaccines

Françoise Mascart, Violette Dirix, and Camille Locht

Chapter 11 Congenerics

Iain MacArthur and Andrew Preston

Chapter 12 Surveillance and diagnostics

Shelly Bolotin, Helen Quinn, and Peter McIntyre

Chapter 14 Pertussis immunity and the epidemiological impact of adult transmission

Aaron A. King, Matthieu Domenech de Cellès, Felicia M.G. Magpantay, and Pejman Rohani

Chapter 15 Public health consequences

Tami H. Skoff, Colin S. Brown, and Gayatri Amirthalingam


Pejman Rohani and Samuel V. Scarpino

End Matter