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PertussisEpidemiology, Immunology, and Evolution$
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Pejman Rohani and Samuel Scarpino

Print publication date: 2018

Print ISBN-13: 9780198811879

Published to Oxford Scholarship Online: February 2019

DOI: 10.1093/oso/9780198811879.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 05 May 2021

Role of vaccine schedules

Role of vaccine schedules

(p.87) Chapter 5 Role of vaccine schedules

Jodie McVernon

Hester de Melker

Oxford University Press

Over the past 60 years, pertussis vaccines have been implemented in national immunization programme schedules at a variety of ages. All countries administer the vaccine as an infant primary series, but the number and exact timing of these doses differ, as do the number and timing of booster doses. In consequence, short-term direct protection of age-appropriately immunized children varies by schedule. This variability influences vaccine impact on the burden of disease, because the risk of severe morbidity and mortality is greatest in early life and decreases thereafter. In addition, vaccine-derived immunity wanes over time, meaning that longer intervals between doses are predicted to increase the risk of breakthrough infections throughout childhood and adolescence, fuelling ongoing transmission and cyclic epidemics. The duration of protection following vaccination is substantially shorter than following infection, although absolute estimates vary widely across populations and studies.

Keywords:   vaccination schedule, booster schedule, pertussis vaccine, whole-cell pertussis vaccine, acellular pertussis vaccine, immunity, waning immunity, antibody persistence, seroepidemiology, effectiveness

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