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Mitonuclear Ecology$
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Geoffrey E. Hill

Print publication date: 2019

Print ISBN-13: 9780198818250

Published to Oxford Scholarship Online: June 2019

DOI: 10.1093/oso/9780198818250.001.0001

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The genomic architecture of eukaryotes

The genomic architecture of eukaryotes

Chapter:
(p.1) 1 The genomic architecture of eukaryotes
Source:
Mitonuclear Ecology
Author(s):

Geoffrey E. Hill

Publisher:
Oxford University Press
DOI:10.1093/oso/9780198818250.003.0001

Eukaryotes are chimeras—the product of an ancient fusion of a bacterium and an archaeon. Mitochondrial genomes only code for a few dozen products, so more than 1000 nuclear genes create most of the phenotype of a mitochondrion. Consequently, to produce a functional electron transport system and enable oxidative phosphorylation within an organism, every gene product of the mitochondrion must function in close association with products of the nuclear genome. This genomic architecture, with some mitochondrial autonomy, is proposed to be necessary to allow local regulation of the electron transport system within mitochondria. A two-genome architecture of eukaryotes sets up the fundamental necessity of mitonuclear coadaptation and has enormous implications for characteristics of complex life.

Keywords:   Eukaryotic evolution, chimera, mitochondria, Ox Phos Wars, chemiosmosis, membrane potential, inner mitochondrial membrane, CORR hypothesis, mitochondrial genome

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