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Mitonuclear Ecology$
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Geoffrey E. Hill

Print publication date: 2019

Print ISBN-13: 9780198818250

Published to Oxford Scholarship Online: June 2019

DOI: 10.1093/oso/9780198818250.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 20 October 2021

The genomic architecture of eukaryotes

The genomic architecture of eukaryotes

(p.1) 1 The genomic architecture of eukaryotes
Mitonuclear Ecology

Geoffrey E. Hill

Oxford University Press

Eukaryotes are chimeras—the product of an ancient fusion of a bacterium and an archaeon. Mitochondrial genomes only code for a few dozen products, so more than 1000 nuclear genes create most of the phenotype of a mitochondrion. Consequently, to produce a functional electron transport system and enable oxidative phosphorylation within an organism, every gene product of the mitochondrion must function in close association with products of the nuclear genome. This genomic architecture, with some mitochondrial autonomy, is proposed to be necessary to allow local regulation of the electron transport system within mitochondria. A two-genome architecture of eukaryotes sets up the fundamental necessity of mitonuclear coadaptation and has enormous implications for characteristics of complex life.

Keywords:   Eukaryotic evolution, chimera, mitochondria, Ox Phos Wars, chemiosmosis, membrane potential, inner mitochondrial membrane, CORR hypothesis, mitochondrial genome

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