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Evolution and Selection of Quantitative Traits$
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Bruce Walsh and Michael Lynch

Print publication date: 2018

Print ISBN-13: 9780198830870

Published to Oxford Scholarship Online: September 2018

DOI: 10.1093/oso/9780198830870.001.0001

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The Neutral Divergence of Quantitative Traits

The Neutral Divergence of Quantitative Traits

(p.425) 12 The Neutral Divergence of Quantitative Traits
Evolution and Selection of Quantitative Traits

Bruce Walsh

Michael Lynch

Oxford University Press

The joint action of genetic drift and mutation results in the divergence of trait means over time. This chapter examines the expected amount of divergence, which forms the basis for a number of tests on whether an observed pattern is either too large relative to drift (suggesting directional selection) or two small (suggesting stabilizing selection). It then applies these results to examine tests for selection over a very diverse range of data sets, ranging from a stratophenetic series of fossils to divergence in gene expression over time. It also examines a number of trait-augmented marked-based tests (such as using the QTLs or GWAS hits for a trait) for departures from neutrality.

Keywords:   Brownian-motion model, detecting selection using fossil sequences, divergence in gene expression, Fst, GWAS, Ornstein-Uhlenbeck model, Orr's QTLST and QTLST-EE sign tests, Qst, QTL, Qx test, stratophenetic series, tSDS test

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