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A Primer of Molecular Population Genetics$
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Asher D. Cutter

Print publication date: 2019

Print ISBN-13: 9780198838944

Published to Oxford Scholarship Online: August 2019

DOI: 10.1093/oso/9780198838944.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 10 May 2021

Recombination and linkage disequilibrium in evolutionary signatures

Recombination and linkage disequilibrium in evolutionary signatures

(p.113) Chapter 6 Recombination and linkage disequilibrium in evolutionary signatures
A Primer of Molecular Population Genetics

Asher D. Cutter

Oxford University Press

Chapter 6, “Recombination and linkage disequilibrium in evolutionary signatures,” explores the role of partial genetic linkage within and between genes in influencing patterns of nucleotide polymorphism and evolutionary change. It introduces the concept of linkage disequilibrium as the non-random association of alleles at different loci, the potential causes of linkage disequilibrium, and different methods to quantify and visualize it. The empirical effects of partial recombination on patterns of linkage disequilibrium in genomes are illustrated with theoretical predictions and natural examples. The phenomena of non-crossover recombination and gene conversion are presented, as is the application of linkage disequilibrium to inferring population demography and the genetic mapping of traits. This chapter lays the foundation for understanding how complete linkage, partial linkage, and no linkage integrate with the other forces in evolutionary theory and with the empirical analysis of molecular population genetic data.

Keywords:   recombination, partial linkage, linkage disequilibrium, gene conversion, non-crossover recombination, selective interference

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