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Huntington's Disease - Oxford Scholarship Online
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Huntington's Disease

Oliver Quarrell

Abstract

Huntington’s disease (HD)―the facts provides an overview of the condition aimed at families and carers understanding the condition. It describes the key features of: a movement disorder, disturbance of mood (affect), and problems with thinking (cognition) and behaviour. The movement problems of chorea, dystonia, and bradykinesia are explained but there is equal emphasis on depression impulsive behaviour and temper outbursts. Understanding the cause of these may help families cope better when they arise. The genetic change is discussed as is its effect on the protein huntingtin. Options for gen ... More

Keywords: Huntington’s disease, chorea, dystonia, bradykinesia, affect (mood), cognition, huntingtin, prenatal diagnosis (PND), preimplantation genetic diagnosis (PGD), anti-sense oligonucleotides (ASO)

Bibliographic Information

Print publication date: 2020 Print ISBN-13: 9780198844389
Published to Oxford Scholarship Online: February 2021 DOI:10.1093/oso/9780198844389.001.0001

Authors

Affiliations are at time of print publication.

Oliver Quarrell, author
Consultant in Clinical Genetics, Sheffield Children's Hospital, Sheffield, UK